Role of NPY and its receptor subtypes in foraging, food hoarding and intake by Siberian hamsters

No Thumbnail Available
Authors
Diane Day
Erin Keen-Rhinehardt
Timothy J Bartness
Issue Date
Type
Journal Article, Academic Journal
Language
Keywords
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract
Role of NPY and its receptor subtypes in foraging, food hoarding, and food intake by Siberian hamsters. Am J Physiol Regul Integr Comp Physiol 289: R29–R36, 2005. First published February 10, 2005; doi:10.1152/ajpregu.00853.2004.—Fasting has widespread physio¬logical and behavioral effects such as increases in arcuate nucleus neuropeptide Y (NPY) gene expression in rodents, including Siberian hamsters. Fasting also stimulates foraging and food hoarding (appet¬itive ingestive behaviors) by Siberian hamsters but does relatively little to change food intake (consummatory ingestive behavior). Therefore, we tested the effects of third ventricular NPY Y1 ([Pro34]NPY) or Y5 ([D-Trp34]NPY) receptor agonists on these in¬gestive behaviors using a wheel running-based food delivery system coupled with simulated burrow housing. Siberian hamsters had 1)no running wheel access and free food, 2) running wheel access and free food, or 3) foraging requirements (10 or 50 revolutions/pellet). NPY (1.76 nmol) stimulated food intake only during the first 4 h postin¬jection (�200–1,000%) and mostly in hamsters with a foraging requirement. The Y1 receptor agonist markedly increased food hoard¬ing (250–1,000%), increased foraging as well as wheel running per se, and had relatively little effect on food intake ( 250%). Unlike NPY, the Y5 agonist significantly increased food intake, especially in foraging animals (�225–800%), marginally increased food hoarding (250–500%), and stimulated foraging and wheel running 4–24 h postinjection, with the distribution of earned pellets favoring eating versus hoarding across time. Across treatments, food hoarding pre¬dominated early postinjection, whereas food intake tended to do so later. Collectively, NPY stimulated both appetitive and consummatory ingestive behaviors in Siberian hamsters involving Y1/Y5 receptors, with food hoarding and foraging/wheel running (appetitive) more involved with Y1 receptors and food intake (consummatory) with Y5 receptors.
Description
Citation
Publisher
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
EISSN
Collections